A report from Understanding Animal Research (UAR) reveals that ten organizations were responsible for 53% of all animal procedures performed in Great Britain during 2025, totaling 1,347,667 out of 2,537,507 procedures. The vast majority of these procedures, accounting for over 99%, involved mice, fish, rats, and birds, and 82% were classified as causing pain equivalent to or less than that of an injection.

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The organizations leading this research included the University of Manchester, The Francis Crick Institute, University of Cambridge, University of Oxford, and others, with each organization providing detailed statistics on their websites as part of their commitment to transparency. This is the eleventh consecutive year that these institutions have reported their collective animal research statistics in alignment with the Home Office's annual report.

The ten organizations and their respective number of procedures for 2025 are as follows:

- The Francis Crick Institute: 216,508

- University of Cambridge: 182,562

- University of Oxford: 176,689

- UCL: 167,637

- Medical Research Council: 150,817

- University of Edinburgh: 131,103

- King's College London: 106,452

- University of Glasgow: 96,038

- University of Manchester: 78,948

- Imperial College London: 40,913

Total: 1,347,667

Additionally, 69 organizations in the UK have proactively published their 2025 animal research statistics, including institutions that conduct or fund such research. All these organizations adhere to the ethical framework known as the ‘3Rs’: replacement, reduction, and refinement in animal research, aimed at minimizing the number of animals used and optimizing their welfare.

More than 130 organizations, including universities and research charities, have signed the Concordat on Openness on Animal Research in the UK, committing to increased transparency regarding the ethical use of animals in scientific research.

Hannah Hobson, UAR's Head of Communications and Engagement, emphasized the importance of maintaining public trust in animal research, highlighting its role in developing medicines, vaccines, and treatments. Dr. Maria Kamper from the University of Manchester reiterated the institution's commitment to responsible research practices and open communication about their work and its implications for animal welfare.